State of Prooxidant and Antioxidant Blood System in Albino Rats under Joint Effect of T-2 Toxin and Salmonellae in the Experiment

Current experimental research on albino rats has studied the effect of salmonellae and T2 toxin on indices of lipid peroxidation (LPO) and antioxidant protection. Joint effect of bacteria and toxicant, especially in a dose of 560.0μg/kg, was characterized by a more evident increase of integral index of blood and liver LPO – malonic dialdehyde (MDA) by 1.7 and 4.4 times, respectively, and also by exhaustion of antioxidant system (AOS) in animals’ organisms comparing with the situation when the animals were separately contaminated. That was proved by the decrease of catalase activity by 24.7% and vitamin E content – by 43.6% in them. The results obtained demonstrated that salmonella infection against the background of intoxication with T-2 toxin significantly disturbed prooxidant-antioxidant balance in the organism that was the most important mechanism for the oxidative stress development.